Histamine H1 receptors and inositol phosphate formation in rat thalamus

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

The distribution of histamine H1-receptors in the rat brain: An autoradiographic study

José Palacios, James K. Wamsley, M. J. Kuhar · Neuroscience · 1981 · 290 citations

Life Sciences, Neurobiology, Neuroscience +7

Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal

David A. McCormick, Anne Williamson · Journal of Neuroscience · 1991 · 283 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

The Cheng-Prusoff relationship: something lost in the translation

Douglas A. Craig · Trends in Pharmacological Sciences · 1993 · 136 citations

Humanities, Linguistics, Translation Studies +4

Quantitative aspects of drug-receptor interactions

K. J. Chang, David J. Triggle · Journal of Theoretical Biology · 1973 · 76 citations

Pharmacy, Pharmacokinetics, Pharmacology +14