Paraoxonase 1 Gene Polymorphisms Do Not Influence the Response to Treatment in Alzheimer’s Disease

Abstract

<i>Background:</i> Acetylcholinesterase inhibitors (AChEIs) are the treatment of choice for patients with Alzheimer’s disease (AD). However, their efficacy is moderate and differs from patient to patient. Recent studies suggest that the Q192R variant of the paraoxonase 1 gene <i>(PON1)</i> might affect individual susceptibility to these drugs. <i>Methods:</i> We investigated the influence of 3 single nucleotide polymorphisms (SNPs) in <i>PON1</i> (rs 662, rs 854560, rs 705381) and the <i>APOE </i>common polymorphism in 101 Polish patients with late-onset AD in response to treatment with AChEIs. <i>Results:</i> No significant differences were observed between carriers and non-carriers of the <i>PON1</i> SNPs or the <i>APOE</i> common polymorphism in terms of treatment response. These results did not change after stratification of <i>APOE</i> status. <i>Conclusion:</i> Our results suggest that both the investigated <i>PON1</i> and <i>APOE</i> common SNPs do not influence treatment response to AChEIs in patients with AD.