Ototoxicity Induced by Furosemide

TLDR

Furosemide is a potent diuretic widely used for its strong salt‑excretion effect and low toxicity. The authors report transient ototoxic effects observed in five patients with impaired renal function receiving high‑dose furosemide. High‑dose intravenous furosemide (3600 mg total) was administered in divided doses over the first 18 hours after renal transplantation. Sixty hours post‑transplant, urine output fell sharply from 80 to 20 ml per hour. No additional information was provided.

Abstract

FUROSEMIDE is a diuretic that has achieved wide use because of its great potency as a saluretic agent and its low order of toxicity. We describe here transient ototoxic effects of high-dose furosemide therapy in five patients with diminished renal function.Case ReportsA 37-year-old woman with marked renal impairment due to radiation nephritis and with normal hearing received a cadaveric renal transplant. A total of 3600 mg of furosemide was given intravenously in divided doses in the 1st 18 hours after transplantation. Sixty hours after transplantation the urine output fell from 80 to 20 ml per hour. A 1600-mg . .