Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

The EMBO Journal · 2000 · 6.5K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +11

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Xiao Huan Liang, Saadiya Jackson, Matthew Seaman et al. · Nature · 1999 · 3.3K citations

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Daniel J. Klionsky, Hagai Abeliovich, Patrizia Agostinis et al. · Autophagy · 2008 · 2K citations · Full text

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