HPLC ENANTIOMERIC SEPARATION OF o,o-DIALKYL-2-BENZYLOXYCARBONYL-AMINOARYLMETHYL-PHOSPHONATES ON CELLULOSE TRIS(3,5-DIMETHYLPHENYL CARBAMATE) AND N-(3,5-DINITROBENZOYL) LEUCINE CSPs

Abstract

Abstract A series of racemic nine o,o-dialkyl-2-benzyloxycarbonyl-aminoarylmethyl-phosphonate enantiomers has been separated by high performance liquid chromatography on cellulose tri(3,5-dimethyl-phenylcarbamate) and N-(3,5-dinitrobenzoyl) leucine (DNB-leu) chiral stationary phases. The chromatographic parameters, the capacity factor (k), separation factor (α), and the resolution factor (Rs) of all solutes are presented. The influence of the mobile phase composition on the enantioselectivity has been discussed. ACKNOWLEDGMENTS This project is supported by the National Natural Science Foundation of P. R. China and the Natural Science Foundation of Shandong Province, P. R. China. The samples in this research were presented by Dr. Qing Dai. The authors would like to thank Professor Hassan Y. Aboul-Enein of King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia for his valuable comments during the preparation of this manuscript. Now, L. Zhou is working in the Institute of Veterinary Medicine, Shandong Provence, P. R. China.