N-methyl-D-aspartate-induced neuronal activation is selectively modulated by σ receptors

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

Erik H.F. Wong, J A Kemp, Tony Priestley et al. · Proceedings of the National Academy of Sciences · 1986 · 1.8K citations · Full text

Life Sciences, Neuroscience, Pharmacology +15

1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.

E Weber, Mark S. Sonders, M Quarum et al. · Proceedings of the National Academy of Sciences · 1986 · 378 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Sigma and phencyclidine-like compounds as molecular probes in biology

European Journal of Medicinal Chemistry · 1988 · 251 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Neocortical epileptogenesis in vitro: studies with N-methyl-D-aspartate, phencyclidine, sigma and dextromethorphan receptor ligands.

Julia Aram, David Martin, Mateusz D. Tomczyk et al. · Journal of Pharmacology and Experimental Therapeutics · 1989 · 100 citations

Medicine, Neuroscience, Pharmacology +13

Comparison of the actions of phencyclidine and sigma ligands on CA1 hippocampal pyramidal neurons in the rat

Alfred T. Malouf, Elizabeth Swearengen, Charles Chavkin · Neuropharmacology · 1988 · 31 citations

Life Sciences, Neuroscience, Pharmacology +14