Palladium‐Catalyzed <i>N</i>‐Demethylation/<i>N</i>‐Acylation of Some Morphine and Tropane Alkaloids

Abstract

Abstract Hydrocodone was converted to various N ‐acyl derivatives via a one‐pot N ‐demethylation/ N ‐acylation protocol catalyzed by palladium(II). The procedure has also been successfully applied to several N ‐methyltropane alkaloids. A plausible mechanism is suggested.