SYNTHETIC APPROACH TOWARD MITOMYCINS. EFFICIENT SYNTHESIS OF MITOSANE PRECURSORS FROM (2,4-PENTADIENYL)-<i>p</i>-QUINONES

Abstract

Abstract Introduction of 2,4-pentadienyl side chain to halogenated p-quinones is performed with (2,4-pentadienyl)trimethylstannane to afford 2-halo-3-(2,4-pentadienyl)-1,4-quinones. Pyrolytic decomposition of the corresponding azidoquinones derived from the obtained haloquinones affords 3H-pyrrolo[1,2-a]indol-5,8-dione derivatives in good yields.