HR‐MAS NMR spectroscopy in the characterization of human tissues: Application to healthy gastric mucosa

Abstract

Abstract The HR‐MAS is an ideal technique for the investigation of intact tissue specimens (10–50 mg) and permits the obtainment of spectra with a resolution comparable to that observed in solution in a time that does not exceed a half of an hour for a routine analysis. The potentialities of HR‐MAS NMR spectroscopy in the identification of the metabolites characterizing the healthy gastric mucosa are here presented. The direct inspection of the 1D 1 H NMR spectra enables only few metabolites to be confidently assigned, and the use of selected 2D experiments strongly amplify the analytical effectiveness of the technique. © 2006 Wiley Periodicals, Inc. Concepts Magn Reson Part A 28A: 430–443, 2006