Concepedia

Optimization of a pharmacophore model for 5-HT4 agonists using CoMFA and receptor based alignment

Morkos Iskander, Lawrence W. Leung, Trevor Buley, Fadi Ayad, J DIIULIO, Yean Yeow Tan, Ian M Coupar

European Journal of Medicinal Chemistry · 2005 · 15 citations · 13 references

DOI

Concepts

References

13

Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins

Richard D. Cramer, David E. Patterson, Jeffrey D. Bunce · Journal of the American Chemical Society · 1988 · 3.9K citations

, , +14

MMFF VI. MMFF94s option for energy minimization studies

Thomas A. Halgren · Journal of Computational Chemistry · 1999 · 1.2K citations

, , +14

Pharmacological characterization of a neuronal receptor for 5-hydroxytryptamine in guinea pig ileum with properties similar to the 5-hydroxytryptamine receptor.

Douglas A. Craig, David E. Clarke · Journal of Pharmacology and Experimental Therapeutics · 1990 · 263 citations

, , +16

Maximally diagonal force constants in dependent angle-bending coordinates. II. Implications for the design of empirical force fields

Thomas A. Halgren · Journal of the American Chemical Society · 1990 · 166 citations

, , +7

Definition and display of steric, hydrophobic, and hydrogen bonding properties of ligand binding sites in proteins using Lee and Richards accessible surface: validation of a high-resolution graphical tool for drug design

Regine S. Bohacek, Colin McMartin · Journal of Medicinal Chemistry · 1992 · 118 citations · Full text

, , +17