Evidence that a ‘dynamic knockout’ in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis

Loop and Subdomain Movements in the Mechanism of <i>Escherichia coli </i>Dihydrofolate Reductase:  Crystallographic Evidence^,

M.R. Sawaya, Joseph Kraut · Biochemistry · 1997 · 666 citations

Life Sciences, Biochemistry, Molecular Biology +17

Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase

Amnon Kohen, Raffaele Cannio, Simonetta Bartolucci et al. · Nature · 1999 · 580 citations

Life Sciences, Biochemistry, Molecular Biology +16

Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

Carol A. Fierke, Kenneth A. Johnson, Stephen J. Benkovic · Biochemistry · 1987 · 502 citations

Life Sciences, Biochemistry, Microbiology +10

A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis

Gira Bhabha, Jeeyeon Lee, Damian C. Ekiert et al. · Science · 2011 · 463 citations

Life Sciences, Biochemistry, Biophysics +17

Crystalline Dihydropteroylglutamic Acid

Raymond L. Blakley · Nature · 1960 · 456 citations