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Peptide synthesis. Part 12. 3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl esters of fluorenylmethoxycarbonyl amino acids as self-indicating reagents for solid phase peptide synthesis
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1988
Year
Fmoc-amino AcidsEngineeringBiochemistryNatural SciencesFluorenylmethoxycarbonyl Amino AcidsPeptide EngineeringPeptide SynthesisOrganic ChemistryPeptide ScienceSelf-indicating ReagentsChemistryHeterocycle ChemistryLiberated Hydroxy ComponentSynthetic ChemistryResin-bound AmineBiomolecular Engineering
The preparation and characterisation of 3,4-dihydro-4-oxo-1,2,3-benzotriazinyl esters (1) of Fmoc-amino acids and their use in solid phase peptide synthesis is described. Ionisation of the liberated hydroxy component (2) by the starting resin-bound amine provides a useful colour indicator of the progress of acylation reactions.