Alterations of p16INK4a tumour suppressor gene in mucoepidermoid carcinoma of the salivary glands

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

James G. Herman, Jeremy R. Graff, Sanna Myöhänen et al. · Proceedings of the National Academy of Sciences · 1996 · 5.6K citations · Full text

Epigenetic Change, Genetics, Dna Methylation +21

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.

Manel Esteller, Montse Sánchez‐Céspedes, Rafael Rosell et al. · PubMed · 1999 · 928 citations

Epigenetic Change, Genetics, Pathology +21

High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma.

Andre L. Reed, Joseph A. Califano, Paul Cairns et al. · PubMed · 1996 · 586 citations

Genetics, Pathology, High Frequency +18

Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients.

Siane Lopes Bittencourt Rosas, Wayne M. Koch, Maria da Glória Carvalho et al. · PubMed · 2001 · 410 citations

Epigenetic Change, Pathology, Epigenetics +16

Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck.

Shi Yu Zhang, Andres J. Klein–Szanto, Edward R. Sauter et al. · PubMed · 1994 · 231 citations

Genetics, Pathology, Amino Acid Change +20