Multifunctional biocompatible coatings on magnetic nanoparticles

Abstract

Methods for coating formation on magnetic nanoparticles used in biology and medicine are considered. Key requirements to the coatings are formulated, namely, biocompatibility, stability, the possibility of attachment of pharmaceutical agents, and the absence of toxicity. The behaviour of nanoparticle/coating nanosystems in the body including penetration through cellular membranes and the excretion rates and routes is analyzed. Parameters characterizing the magnetic properties of these systems and their magnetic controllability are described. Factors limiting the applications of magnetically controlled nanosystems for targeted drug delivery are discussed. The bibliography includes 405 references.