Cold Spring Harbor Symposia on Quantitative Biology · 1963 · 285 citations · 0 references
Life SciencesGeneticsMicrobiologyBacteriologyEnzymologyMicrobial MetabolismAmino Acid MetabolismBacterial MetabolismMicrobial Metabolite ProductionOperon OrganizationOperon StructureEnzymesHis OperonHistidine BiosynthesisHistidine MetabolismMicrobial MetabolitesPhosphoribosyl Pyrophosphate Metabolism
A series of ten enzymes in Salmonella typhimurium convert the 5-carbon chain of phosphoribosyl pyrophosphate to the 5-carbon chain of histidine (Fig. 1). The pathway of histidine biosynthesis has no branches giving rise to other essential metabolites. Most of the intermediates of the pathway have been characterized and assays for 8 of the 10 enzymes are in routine use.