Immunogenicity and Immunologic Memory of Meningococcal C Conjugate Vaccine in Premature Infants

Abstract

MCC vaccine is immunogenic and primes for immunologic memory in preterm infants. The decreased memory responses in these preterm infants in conjunction with waning clinical efficacy data for all U.K. infants suggest a role for a routine booster dose of vaccine in all infants receiving MCC, especially those born preterm.