Syntheses and reactions of some 2,3‐disubstituted pyrazine monoxides

Abstract

Abstract The reactions of 2,3‐dimethyl‐ ( 4 ), 2,3‐diphenyl‐ ( 6 ), and 2‐methyl‐3‐phenyl‐pyrazine monoxides ( 8 and 9 ) with phosphoryl chloride and acetic anhydride resulted in giving monochloro‐ and monacetoxy‐pyrazines in almost all cases. However, the reaction of 6 with acetic anhydride afforded exceptionally a diacetoxydihydro‐pyrazine. These products were converted further to hydroxy or dichloro derivatives.