Binding of Anilide-type Local Anesthetics in Human Plasma

Abstract

The rank-order of binding in human plasma for a series of anilide-type local anesthetics, determined by ultrafiltration and gas chromatography, was: bupivacaine > mepivacaine > lidocaine > the N-dimethyl analog of lidocaine. Drugs were added to plasma in citro, pH maintained at 7.4±0.1 and temperatu