Isothermal Titration Calorimetry Studies on the Binding of DNA Bases and PNA Base Monomers to Gold Nanoparticles

A. Gourishankar, Sourabh Shukla, Krishna N. Ganesh, Murali Sastry

Journal of the American Chemical Society · 2004 · 139 citations · 8 references

Concepts

Abstract

An isothermal titration calorimetric (ITC) investigation of the interaction of DNA bases and PNA base monomers with gold nanoparticles is described revealing a binding sequence in the order C > G > A > T. Direct measurement of the strength of interaction of ligands with nanogold by ITC has important implications in surface modification strategies for biomedical, catalysis, and nanoarchitecture applications.

References

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