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Process Development of Selectively Benzoylated and Fluorinated Glycosyl Donors
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2010
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Combinatorial ChemistryRoute SelectionGlycobiologyOrganic ChemistryPharmaceutical ChemistryMedicinal ChemistryGlycosylationBiochemistryFluorous SynthesisDrug DevelopmentPharmacologyBiomolecular EngineeringGlycosyl DonorsNatural SciencesSelectively BenzoylatedMedicineSglt Inhibitor Sar7226Carbohydrate-protein InteractionDrug Discovery
Route selection, process development and large-scale preparation of selectively benzoylated and fluorinated d-glucopyranoses, required as glycosyl donors for the synthesis of the SGLT inhibitor SAR7226, are discussed.