Publication | Closed Access
THE IMMUNOSUPPRESSIVE ACTIVITY OF ARA-CYTIDINE (CYTARABINE)
16
Citations
0
References
1969
Year
ImmunologyCanine Renal TransplantationPharmacotherapyImmunotherapyCytarabine InjectionsHematologyGraft SurvivalImmunochemistryCell TransplantationTransplantationXenotransplantationKidney TransplantCytosine ArabinosideUrologyImmunosuppressive ActivityImmunosuppressive TherapyKidney TransplantationImmunosuppressionMedicineNephrologyGraft Rejection
SUMMARY The effect of cytarabine (ara-cytidine, cytosine arabinoside), a potent antitumor and immunosuppressive agent, on canine renal transplantation has been studied. Cytarabine did not prolong the survival of the renal allografts although a modification of the histological pattern of rejection was observed. In contrast, the antibody (hemagglutinin) response induced by injections of sheep red blood cells was significantly suppressed by cytarabine. In addition, the appearance of both total and mercaptoethanol-resistant antibody titers were delayed. Cytarabine injections in normal and kidney transplant dogs resulted in a general leukopenia. No selectivity for leukocyte type was observed.