Concepedia

The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study

J Koška, Joy C. Bunt, Adeline Gasser, J. Impson, Robert L. Hanson, Josephine M. Forbes, Barbora de Courten, Jonathan Krakoff

Diabetologia · 2008 · 119 citations · 31 references

DOIFull text

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Abstract

The glucose-lowering potential of salicylates appears to be due to effects on insulin concentration rather than improved insulin action. Salicylate-based compounds may be useful for the treatment and prevention of type 2 diabetes.

References

31

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Dongsheng Cai, Minsheng Yuan, Daniel Frantz et al. · Nature Medicine · 2005 · 2.2K citations · Full text

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Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>

Minsheng Yuan, Nicky Konstantopoulos, Jongsoon Lee et al. · Science · 2001 · 1.9K citations

IKK-β links inflammation to obesity-induced insulin resistance

Melek C. Arkan, Andrea L. Hevener, Florian R. Greten et al. · Nature Medicine · 2005 · 1.7K citations

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INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*

Robert D. Steele · Annals of the New York Academy of Sciences · 1959 · 1.7K citations

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The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

Min-Jean Yin, Yumi Yamamoto, Richard B. Gaynor · Nature · 1998 · 1.6K citations

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