Journal of Natural Products · 2003 · 44 citations · 8 references
Natural SciencesMarine BiologyMarine SciencesDrug DiscoveryEcotoxicologyMarine EcologyMarine Bioactive CompoundsMarine Natural ProductsAntifouling CompoundsBioactive Compounds From Marine SpongesMarine Sponge MetabolitesRepellent EfficacySponges-derived Metabolites
Bioassay-guided fractionation of an extract of the sponge Haliclona sp. provided a known hexapeptide, waiakeamide (1), and a new sulfone derivative (2). The structures of hexapeptides 1 and 2 were elucidated by extensive NMR analyses and the advanced Marfey's method with LC/MS. These compounds showed repellent activity against the blue mussel, Mytilus edulis galloprovincialis.
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