Acute tryptophan and serotonin depletion using an optimized tryptophan-free protein–carbohydrate mixture in the adult rat

Brain Serotonin Content: Increase Following Ingestion of Carbohydrate Diet

John D. Fernstrom, Richard J. Wurtman · Science · 1971 · 731 citations

Life Sciences, Neuroscience, Physiology +17

Tryptophan depletion causes a rapid lowering of mood in normal males

Simon N. Young, Scott E. Smith, Robert O. Pihl et al. · Psychopharmacology · 1985 · 720 citations

Medicine, Psychiatry, Psychopharmacology +4

Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: interactions with dopaminergic mechanisms

Amanda Harrison, Barry J. Everitt, Trevor W. Robbins · Psychopharmacology · 1997 · 456 citations

Medicine, Neuroscience, Psychology +16

Serotonin depletion during synaptogenesis leads to decreased synaptic density and learning deficits in the adult rat: a possible model of neurodevelopmental disorders with cognitive deficits

Carrie Mazer, Jennifer Muneyyirci, Kenneth Taheny et al. · Brain Research · 1997 · 285 citations

Medicine, Neurobiology, Neuroscience +17

Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindoleacetic acid by a tryptophan-free diet

Giovanni Biggio, Fabio Fadda, Patrizia Fanni et al. · Life Sciences · 1974 · 267 citations

Life Sciences, Neurobiology, Neuroscience +8