ON THE PATHOPHYSIOLOGY OF THE INCREASED CEREBROVASCULAR PERMEABILITY IN ACUTE ARTERIAL HYPERTENSION IN CATS

Abstract

Hypertension was induced by intravenous injection of Aramine in cats, either abruptly or stepwise. Evans Blue was used as a tracer for observations on the permeability of the cerebral vessels. In the cats with abrupt pressure increase extravasation of Evans Blue occurred in the brains indicating increased permeability to proteins. It is suggested that the permeability changes are due to a mechanical distension of the vessel wall caused by the sudden increase of the intraluminal pressure.