Biotechnology and Bioengineering · 1985 · 53 citations · 7 references
Life SciencesBioengineeringBiotechnologyBiochemical EngineeringBioprocess EngineeringOptimizationBioprocess ModelingBioprocess OptimizationFermentation KineticsFermentation Process ControlIndustrial FermentationYeast BiologyAdaptive OptimizationContinuous Bioprocess OptimizationDynamic Model IdentificationDynamic Parameter IdentificationFermentation ModelingFermentation Process EngineeringModel IdentificationProductivity
An adaptive on-line optimization method that utilizes dynamic model identification has been applied to maximize the cellular productivity of a continuous bakers' yeast culture. Experiments were conducted on a sophisticated computerized fermentation system. Experimental results show that the adaptive on-line optimization method requires very little a priori information, is easy to implement, converges quickly, adapts to changes in the process, and is stable even when operational difficulties are encountered.
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