Phosphorylation of sodium channels mediated by protein kinase‐C modulates inhibition by topiramate of tetrodotoxin‐sensitive transient sodium current

Abstract

These data show that PKC-activation can modulate the effect of topiramate on I(NaT). This suggests that channel phosphorylation in physiological or pathological conditions (such as epiliepsy), can alter the action of topiramate on sodium currents.