New paraherquamide antibiotics with anthelmintic activity.

Abstract

Paraherquamide (1) an anthelmintic alkaloid, was isolated from a species of Penicillium along with three novel analogues 2, 3 and 4. Anthelmintic activity at least equal to that of paraherquamide is described for the 14-de-hydroxy compound, VM 54159 (4).