The Relation Between Response to Hypotonic Stress and the ⁵¹Cr Recovery In Vivo of Preserved Platelets

Abstract

Platelet response to hypotonic stress can be used to estimate the 51 Cr recovery in vivo of liquid‐ and freeze‐preserved platelets. This simple in vitro test may prove helpful in determining and controlling the quality of preserved platelets. In our study, the response to hypotonic stress was not related to the 51 Cr T‐1/2 value of the preserved platelets, but was related to the number of irreversibly damaged platelets removed within two hours after transfusion.