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Synthetic studies of (.+-.)-lysergic acid and related compounds.
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1987
Year
Medicinal ChemistryBiosynthesisBioorganic ChemistryEngineeringBiochemistrySimple MethodNatural SciencesBiocatalysisFour-step SequenceBiotransformationHigh YieldRelated CompoundsPharmacologyChemical DerivativeSynthetic ChemistryBiomolecular EngineeringNatural Product Synthesis
A new and simple method for a formal synthesis of (±) -lysergic acid (1), via a four-step sequence starting from the aldehyde (13), is described. A very high yield of the product was obtained after purification by column chromatography at the end of the process, without isolation of intermediates.