Publication | Closed Access
Total synthesis of hygromycin A
25
Citations
0
References
1989
Year
Protected Sugar MoietyMedicinal ChemistryBiosynthesisBiochemistryMedicineNatural SciencesGlycobiologyTotal SynthesisAntibiotic HygromycinCarbohydrate-protein InteractionStereoselective SynthesisAntimicrobial CompoundPharmacologyAunthentic SamplePharmaceutical ChemistrySynthetic ChemistryNatural Product Synthesis
The first complete synthesis of antibiotic hygromycin A is reported; coupling of the protected sugar moiety (2) and the aminocyclitol (3) derived from D-glucose as the optically active from, followed by deprotection, gives the product (1) which was identified with an aunthentic sample by 400 MHz 1H n.m.r. spectroscopy.