Comparative effect of 6S, 6R and 6RS Leucovorin on methotrexate rescue and on modulation of 5-fluorouracil

Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil and high-dose folinic acid.

D. Machover, Emma Goldschmidt, P. Chollet et al. · Journal of Clinical Oncology · 1986 · 397 citations

Medicine, Oncology, Pharmacotherapy +10

Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil.

Ronald M. Evans, Laskin Jd, Hakala Mt · PubMed · 1981 · 283 citations

Medicine, Biochemistry, Pharmacology +14

Deranged DNA Synthesis by Bone Marrow from Vitamin B₁₂‐Deficient Humans*

J. Metz, A. K. Kelly, Virginia C. Swett et al. · British Journal of Haematology · 1968 · 231 citations

Medicine, Hematology, Bone Metabolism +15

Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products.

John J. McGuire, Pearl Hsieh, James K. Coward et al. · Journal of Biological Chemistry · 1980 · 215 citations · Full text

Life Sciences, Biochemistry, Enzymology +7

Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.

Buddy Ullman, M Lee, David W. Martin et al. · Proceedings of the National Academy of Sciences · 1978 · 195 citations · Full text

Medicine, Oncology, Pharmacology +14