Concepedia

Spiradoline, a kappa opioid receptor agonist, produces tonic- and use-dependent block of sodium channels expressed in Xenopus oocytes

Michael K. Pugsley, Esther J. Yu, Alan L. Goldin

General Pharmacology The Vascular System · 2000 · 10 citations · 36 references

DOI

Concepts

References

36

A quantitative description of membrane current and its application to conduction and excitation in nerve

A. L. Hodgkin, A. F. Huxley · The Journal of Physiology · 1952 · 23.2K citations · Full text

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Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

Bertil Hille · The Journal of General Physiology · 1977 · 1.8K citations · Full text

, , +16

Molecular Determinants of State-Dependent Block of Na <sup>+</sup> Channels by Local Anesthetics

David S. Ragsdale, Jancy C. McPhee, Todd Scheuer et al. · Science · 1994 · 861 citations

, , +17

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

James W. West, D E Patton, Todd Scheuer et al. · Proceedings of the National Academy of Sciences · 1992 · 839 citations

, , +17

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel

Lori L. Isom, K De Jongh, Dennis D. Patton et al. · Science · 1992 · 702 citations

, , +17