Publication | Closed Access
Synthesis of 5,6‐Spiroethers and Evaluation of their Affinities for the Bacterial A Site
25
Citations
15
References
2011
Year
Bioorganic ChemistryEngineeringRna RecognitionRibosomal RnaMolecular BiologyChemical BiologyMedicinal ChemistryMaximizing AffinityEnvironmental MicrobiologyMolecular RecognitionBiochemistryRna Structure PredictionRna BiologyAntibacterial AgentAntimicrobial CompoundStructural BiologyAntibioticsNatural SciencesSynthetic BiologyBacterial A SiteMicrobiologyDrug Discovery
Exploring RNA recognition: Maximizing affinity for the A site of ribosomal RNA is a task met with a set of spirocyclic compounds that are presented in this work. The chemical syntheses, the biological evaluation and a computational justification of this interesting low-nM fluorescence-based activity are presented.
| Year | Citations | |
|---|---|---|
Page 1
Page 1