Synthesis of 5,6‐Spiroethers and Evaluation of their Affinities for the Bacterial A Site

Abstract

Exploring RNA recognition: Maximizing affinity for the A site of ribosomal RNA is a task met with a set of spirocyclic compounds that are presented in this work. The chemical syntheses, the biological evaluation and a computational justification of this interesting low-nM fluorescence-based activity are presented.