Journal of Internal Medicine · 2003 · 329 citations · 27 references
The HMGB1 acts as a potent pro-inflammatory cytokine on HUVEC and the activity is mainly mediated through the B-box of the protein. HMGB1 may be a key factor mediating part of the pro-inflammatory response occurring in septic shock and severe inflammation.
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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Paola Scaffidi, Tom Misteli, Marco E. Bianchi · Nature · 2002 · 4.1K citations
Inflammation, Chromatin, Cytokine +10
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Haichao Wang, Ona Bloom, Minghuang Zhang et al. · Science · 1999 · 3.4K citations