Modern Rheumatology · 2012 · 19 citations · 12 references
Life SciencesGeneticsImmunologyAutoimmunityImmunogeneticsMedical GeneticsAnkylosing SpondylitisAutoimmune Disease Susceptibility GenesAutoimmune DiseasesGenetic Susceptibility To AutoimmunityKiller Cell Immunoglobulin-like Receptor GeneticsPopulation ImmunogeneticsActivating Killer Cell Immunoglobulin-like ReceptorsAutoimmune Disease GeneticsControl Group DesignHla Autoimmune Disease AssociationsHuman Leukocyte Antigen B27Killer Cell Immunoglobulin-like Receptor Gene PolymorphismKiller-cell Immunoglobulin-like ReceptorsMatched Control Group
OBJECTIVE: Recent studies have explored the role of killer cell immunoglobulin-like receptors (KIRs) in chronic autoimmune diseases. The purpose of this study was to demonstrate whether KIR genes contribute to the pathogenesis of ankylosing spondylitis (AS) in Chinese populations. METHODS: Sixteen KIR genes were genotyped from 60 unrelated patients with AS and 60 HLA-B27-positive matched healthy controls by PCR-SSP. The frequencies of the KIR alleles and genotypes in the AS and control groups were assessed by the χ(2) test. RESULTS: Our results showed that the frequency of the activator receptor KIR3DS1 gene in the AS group was significantly increased compared to the controls (χ(2) = 5.263, P = 0.006, OR = 3.059, 95 % CI = 1.357-6.896). Moreover, the frequency of the KIR3DL1/3DS1 genotype was greater in the AS group than in the control group (P = 0.039, OR = 3.059, 95 % CI = 1.357-6.896). In contrast, the frequency of the no KIR3DL1/no 3DS1 genotype was lower in patients with AS compared with the controls (P = 0.032, OR = 0.110, 95 % CI = 0.013-0.911). CONCLUSION: KIR3DS1, in addition to HLA-B27, may play an important independent role in the pathogenesis of AS in the Chinese population.
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Expansion of unusual CD4+ T cells in severe rheumatoid arthritis
Peter Martens, Jörg J. Goronzy, Daniel J. Schaid et al. · Arthritis & Rheumatism · 1997 · 288 citations