Studies in a tumor spectrum.II. The growth of a variety of mouse and rat tumors

Abstract

HE EFFECTIVENESS of 2,4,6-triethylenimino-s-T triazine in the inhibition of the development of leukemia4v5 and of sarcoma 180 in mice29 3* 19 made it a candidate for study in a tumor spectrum.20723 I n addition, results in experimental animal tumors reported from other laboratories09 9, iol 133 17 and in human cancer117 l2, 16, 24 have indicated that this compound merited intensive study.Our observations on the effect of this compound on a variety of transplantable mouse and rat tumors have been briefly reported19, z2 and are now presented in more detail. MATERIALS AND METHODS2,4,6-Triethylenimino-s-triazine, referred to hy its short designation, TEM, has this formula: