Prognosis of granulosa-theca tumors of the ovary

Abstract

The clinical and pathologic findings of 203 patients with granulosa-theca tumors were analyzed to determine the features related to subsequent behavior of the tumor. The neoplasms were divided into three groups—granulosa tumors, mixed granulosa-theca tumors and thecomas. The actuarial survival rates of patients with granulosa tumors and mixed granulosa-theca tumors were nearly identical—both 97% at 5 years and 93% at 10 years. Only one of the 106 patients with a thecoma died of tumor, the other lesions being clinically and histologically benign. Capsular invasion and lymphatic invasion by the neoplasm were features associated with persistence of the tumor but the type of treatment, the degree of cellular atypism and mitotic activity were not. Unilateral oophorectomy is adequate therapy for granulosa-theca tumors confined to the ovary if biopsy and frozen-section examination are done on any suspicious lesion of the opposite ovary or other pelvic structure.