Codon catalog usage is a genome strategy modulated for gene expressivity
Nucleic Acids Research · 1981 · 949 citations · 37 references
GeneticsMolecular BiologyNew SeriesGenomicsGene TranscriptionSequence AlignmentMolecular EcologyComputational GenomicsGene StructureGenome AnalysisCodon Catalog UsageSequence AnalysisGenome StructureCodon UseGene ExpressionFunctional GenomicsBioinformaticsGene ExpressivityBiologyNew GenesGene Sequence AnnotationGenome StrategyNatural SciencesGenetic EngineeringMicrobiologySystems BiologyMedicineGenome EditingSequence Assembly
The nucleic acid sequence bank now holds 161 mRNAs, including 43 newly added genes, while the B. mori fibroin sequence was omitted due to uncertain translation start. The study introduces a new series of correspondence analyses on codon usage to test the genome hypothesis. The authors provide codon frequency tables for each added gene and genome type and propose that bacterial mRNA expression is regulated by third‑base choices between quartet and duet codons.
The nucleic acid sequence bank now contains 161 mRNAs, 43 new genes are added. One sequence, that of B. mori fibroin, is dropped due to uncertainty on the starting point for translation. Frequencies of all codons are given for each gene added and for each genome type in the total bank. A new series of correspondence analyses on codon use is presented, substantiating the genome hypothesis. Internal regulation of mRNA expression by different third base choices between quartet and duet codons is proposed for bacterial genes.
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