Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

Mark S. Anderson, Emily S. Venanzi, Ludger Klein et al. · Science · 2002 · 2.4K citations

Immunology, Immune Regulation, Antigen Processing +18

Claudin-based tight junctions are crucial for the mammalian epidermal barrier

Mikio Furuse, Masaki Hata, Kyoko Furuse et al. · The Journal of Cell Biology · 2002 · 1.5K citations · Full text

Positional cloning of the APECED gene

Kentaro Nagamine, Pärt Peterson, Hamish S. Scott et al. · Nature Genetics · 1997 · 1.4K citations

Genetics, Gene Structure, Dna Replication +6

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

Johanna Aaltonen, Petra Björses, Jaakko Perheentupa et al. · Nature Genetics · 1997 · 1.2K citations

Autoimmune Disease, Novel Gene, Autoantibody Production +11

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

Jens Derbinski, Antje Schulte, Bruno Kyewski et al. · Nature Immunology · 2001 · 1K citations

Promiscuous Gene Expression, Lineage Plasticity, Developmental Biology +11