Planta Medica · 2007 · 39 citations · 0 references
Life SciencesBotanyPharmacologyMolecular VirologyPlant BiochemistryVirologyAntiviral AgentsAntiviral PharmacologyEnzyme InhibitionGreen AlgaeMedicinal PlantsVirus-host InteractionsAntimicrobial Marine CompoundsAntiviral Marine CompoundsAntiviral Mechanisms Of ActionAntiviral Natural ProductsAntiviral Structure-activity RelationshipsMarine-derived Antimicrobial CompoundsMarine-derived Antiviral CompoundsNucleoside Reverse Transcriptase Inhibitors
The meroditerpenoids atomaric acid (1), epitaondiol (2) and the peroxylactone of 5'a-desmethyl-5'-acetylatomaric acid (3) were isolated from the Brazilian brown alga Stypopodium zonale collected in two localities (Búzios and Marataízes, RJ and ES States). These compounds showed strong anti-HSV-1 activity in vitro but neither of them inhibited the transcriptase reverse enzyme of HIV-1.