Concepedia

Formal γ-alkynylation of ketonesvia Pd-catalyzed C–C cleavage

Asraa Ziadi, Arkaitz Correa, Rubén Martı́n

Chemical Communications · 2012 · 68 citations · 40 references

DOI

Concepts

Abstract

A formal γ-alkynylation of ketones via Pd-catalyzed C-C bond-cleavage is presented. The method allows for the coupling of tert-cyclobutanols and bromoacetylenes, giving access to versatile alkynes that are beyond reach otherwise.

References

40

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.5K citations

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Ruthenium-Catalyzed Azide−Alkyne Cycloaddition: Scope and Mechanism

Brant C. Boren, Sridhar Narayan, Lars K. Rasmussen et al. · Journal of the American Chemical Society · 2008 · 804 citations

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CuBr-Catalyzed Efficient Alkynylation of sp<sup>3</sup> C−H Bonds Adjacent to a Nitrogen Atom

Zhiping Li, Chao‐Jun Li · Journal of the American Chemical Society · 2004 · 665 citations

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Cu-catalyzed cross-dehydrogenative coupling: A versatile strategy for C–C bond formations via the oxidative activation of sp <sup>3</sup> C–H bonds

Zhiping Li, D. Scott Bohle, Chao‐Jun Li · Proceedings of the National Academy of Sciences · 2006 · 592 citations · Full text

, , +14

Cyclobutanes in Catalysis

Tobias Seiser, Tanguy Saget, Duc N. Tran et al. · Angewandte Chemie International Edition · 2011 · 590 citations · Full text

, , +10