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LIVER GLUCOSE-6-PHOSPHATASE ACTIVITY AND INTRACELLULAR DISTRIBUTION AFTER CORTISONE ADMINISTRATION1
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1956
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HepatotoxicityMetabolic StateHealth SciencesBiochemistryLiver PhysiologyMetabolomicsEndocrinologyPharmacologyDrug-induced Liver InjuryLiverLiver G-6-pase ActivityLiver Glucose-6-phosphataseHepatologyDiabetesPhysiologyMetabolic RegulationLiver DiseaseMetabolismMedicineAdult Liver
THE behavior of liver glucose-6-phosphatase (G-6-Pase) in various physiological and pathological conditions has recently been under investigation in this laboratory. It was shown that in adult rats and mice, liver G-6-Pase activity increased in fasting (Weber and Cantero, 1954). On the other hand, G-6-Pase activity progressively decreased in the precancerous liver of 4-dimethylaminoazobenzene fed rats and it was almost completely absent in the developed hepatoma. The transplantable Novikoff rat hepatoma and various transplantable mouse tumors showed no G-6-Pase activity (Weber and Cantero, 1955). Studies in regenerating liver showed that this enzyme was not affected in the rapidly growing adult liver. On the other hand, almost no enzymatic activity was present in the 16 and 19 day old rat embryos (Weber and Cantero, 1955). These changes in the liver G-6-Pase activity under different physiological and pathological conditions have focussed our interest upon the factors which may influence the G-6-Pase reaction in vivo.