KDIGO Clinical Practice Guidelines for Acute Kidney Injury

TLDR

KDIGO guidelines classify recommendations into levels, with level 2 being discretionary suggestions that may vary across clinical contexts. Recommendations are graded A–D based on evidence quality and cover four domains: AKI definition, prevention/treatment, contrast‑induced AKI, and dialysis interventions. The guideline’s evidence strength is summarized in Table 1, and key clinical statements are summarized online at www.kdigo.org.

Abstract

tion’, implying that most patients ‘should’ receive a particular action. In contrast, level 2 guidelines are essentially ‘suggestions’ and are deemed to be ‘weak’ or discretionary, recognising that management decisions may vary in different clinical contexts. Each recommendation was further graded from A to D by the quality of evidence underpinning them, with grade A referring to a high quality of evidence whilst grade D recognised a ‘very low’ evidence base. The overall strength and quality of the supporting evidence is summarised in table 1 . The guidelines focused on 4 key domains: (1) AKI definition, (2) prevention and treatment of AKI, (3) contrastinduced AKI (CI-AKI) and (4) dialysis interventions for the treatment of AKI. The full summary of clinical practice statements is available at www.kdigo.org, but a few key recommendation statements will be highlighted here.