Hybrid insulin cocrystals for controlled release delivery

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

New England Journal of Medicine · 1993 · 24.7K citations · Full text

Medicine, Endocrinology, Internal Medicine +14

Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study

Yasuo Ohkubo, Hideki Kishikawa, Eiichi Araki et al. · Diabetes Research and Clinical Practice · 1995 · 3.1K citations

Medicine, Endocrinology, Internal Medicine +15

The structure of 2Zn pig insulin crystals at 1.5 Å resolution

Edward N. Baker, T.L. Blundell, J.F. Cutfield · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1988 · 673 citations

Life Sciences, Biochemistry, Biophysics +17

Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect <i>in vivo</i>

Peter Kurtzhals, Svend Havelund, Inge Jonassen et al. · Biochemical Journal · 1995 · 329 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer

Urszula Derewenda, Zygmunt S. Derewenda, E.J. Dodson et al. · Nature · 1989 · 319 citations

Life Sciences, Biochemistry, Molecular Biology +10