Studies on the Pathogenesis of Rheumatoid Joint Inflammation

Abstract

Article1 February 1965Studies on the Pathogenesis of Rheumatoid Joint InflammationII. Intracytoplasmic Particulate Complexes in Rheumatoid Synovial FluidsARNOLD J. RAWSON, M.D., NEVA M. ABELSON, M.D., JOSEPH LEE HOLLANDER, M.D., F.A.C.P.ARNOLD J. RAWSON, M.D., NEVA M. ABELSON, M.D., JOSEPH LEE HOLLANDER, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-2-281 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe finding of large dark intracytoplasmic inclusion granules in unstained synovial fluids from rheumatoid arthritis joints has suggested the possibility that complexes of some form of gamma globulin and rheumatoid factor may be phagocytized in this disease (1). It has been previously demonstrated that such complexes are phagocytized by normal leukocytes in vitro (2).The purpose of the present study is to examine a wide variety of joint fluids by specific immunologic techniques in an attempt to determine whether gamma globulin-rheumatoid factor complexes are present within the cytoplasm of joint fluid leukocytes and, if so, under what conditions these occur....References1. HOLLANDERRAWSONRESTIFOLUSSIER JLAJRAAJ: Studies on the pathogenesis of rheumatoid joint inflammation (abstract). Arthritis Rheum. 7: 314, 1964. Google Scholar2. PARKERSCHMID RLFR: Phagocytosis of particulate complexes of γ globulin and rheumatoid factor. J. Immun. 88: 519, 1962. MedlineGoogle Scholar3. VOGTRUBIN PKH: Localization of infectious virus and viral antigen in chick fibroblasts during successive stages of infection with Rous sarcoma virus. Virology 13: 528, 1961. CrossrefMedlineGoogle Scholar4. ABELSONRAWSON NMAJ: The reactions between blood group antibodies and antisera to purified immunoglobulins. Transfusion 3: 469, 1963. CrossrefMedlineGoogle Scholar5. OUCHTERLONY O: Diffusion-in-gel methods for immunological analysis. Progr. Allerg. 5: 1, 1958. MedlineGoogle Scholar6. COMAN DR: The effect of prontosil and related compounds upon the chemotropism of leukocytes. Amer. J. Med. Sci. 196: 273, 1938. CrossrefGoogle Scholar7. HESSZIFF EM: A fluorescent test for the rheumatoid factor in blood. Arthritis Rheum. 4: 574, 1961. CrossrefMedlineGoogle Scholar8. HIRSCHCOHN JGZA: Leukocyte lysosomes, in "Cell-Bound Antibodies," edited by AMOS, B., KOPROWSKI, H., Wistar Institute Press, Philadelphia, 1963, p. 45. Google Scholar9. URIUHARA T: Phagocytosis of antigen-antibody complexes. Fed. Proc. 23: 390, 1964. Google Scholar10. LEHMANKREAMBERKOWITZKAMBOLISBROGNA MAJSSCD: The occurrence of acid and alkaline phosphatase in synovial fluids and its clinical significance (abstract). Arthritis Rheum. 6: 283, 1963. Google Scholar11. FRANGIONECOOPERMCEWEN BNSC: "Rheumatoid" factor in rheumatoid "variants" (abstract). Arthritis Rheum. 6: 772, 1963. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ARNOLD J. RAWSON, M.D.; NEVA M. ABELSON, M.D.; JOSEPH LEE HOLLANDER, M.D., F.A.C.P.Affiliations: Philadelphia, PennsylvaniaFrom the Department of Pathology, University of Pennsylvania School of Medicine, the William Pepper Laboratory of Clinical Medicine, and the Arthritis Clinic, Hospital of the University of Pennsylvania, Philadelphia, Pa.Requests for reprints should be addressed to Joseph Lee Hollander, M.D., Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pa. 19104. 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The "R.A. Cell" and a Working HypothesisJOSEPH LEE HOLLANDER, M.D., F.A.C.P., DANIEL J. MCCARTY JR., M.D., F.A.C.P., GONZALO ASTORGA, M.D., EDUARDO CASTRO-MURILLO, M.D.Studies on the Pathogenesis of Rheumatoid Joint Inflammation III. The Experimental Production of Arthritis by the Intra-articular Injection of Purified 7S Gamma GlobulinRONALD A. RESTIFO, M.D., ANDRE J. LUSSIER, M.D., ARNOLD J. RAWSON, M.D., JOHN H. ROCKEY, M.D., JOSEPH LEE HOLLANDER, M.D., F.A.C.P. 1 February 1965Volume 62, Issue 2Page: 281-284KeywordsArthritisCytoplasmGlobulinsHospital medicineInflammationPathogenesisPathology and laboratory medicineResearch laboratoriesRheumatoid arthritisSynovial fluid ePublished: 1 December 2008 Issue Published: 1 February 1965 PDF downloadLoading ...