Involvement of Heparin-Binding EGF-like Growth Factor and Its Processing by Metalloproteinases in Early Epithelial Morphogenesis of the Submandibular Gland

An Essential Role for Ectodomain Shedding in Mammalian Development

Jacques J. Peschon, Jennifer L. Slack, P. Linga Reddy et al. · Science · 1998 · 1.6K citations

Life Sciences, Cell Biology, Molecular Biology +10

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

Norbert Prenzel, Esther Zwick, Henrik Daub et al. · Nature · 1999 · 1.5K citations

Life Sciences, Biochemistry, Molecular Biology +15

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

Shigeki Higashiyama, Judith A. Abraham, John C. Fiddes et al. · Science · 1991 · 1.1K citations

Life Sciences, Cancer Biology, Cell Biology +14

A metalloprotease–disintegrin, MDC9/meltrin‐γ/ADAM9 and PKCδ are involved in TPA‐induced ectodomain shedding of membrane‐anchored heparin‐binding EGF‐like growth factor

Yasushi Izumi · The EMBO Journal · 1998 · 518 citations

Life Sciences, Biochemistry, Molecular Biology +7

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

Alane Gray, Thomas J. Dull, Axel Ullrich · Nature · 1983 · 513 citations

Life Sciences, Biochemistry, Molecular Biology +5