Distinct Patterns of Endothelin Axis Expression in Primary Prostate Cancer

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature · 1988 · 10.8K citations · Full text

Life Sciences, Cell Biology, Physiology +9

Cloning and expression of a cDNA encoding an endothelin receptor

Hiroshi Arai, Seiji Hori, Ichiro Aramori et al. · Nature · 1990 · 2.6K citations

Life Sciences, Cell Biology, Physiology +7

Identification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostate

Joel B. Nelson, Sean P. Hedican, Daniel J. George et al. · Nature Medicine · 1995 · 623 citations

Medicine, Oncology, Urology +12

Hypermethylation of CpG Islands in Primary and Metastatic Human Prostate Cancer

Srinivasan Yegnasubramanian, Jeanne Kowalski, Mark L. Gonzalgo et al. · Cancer Research · 2004 · 529 citations · Full text

Medicine, Genetics, Oncology +17

Effect of Endothelin-A Receptor Blockade With Atrasentan on Tumor Progression in Men With Hormone-Refractory Prostate Cancer: A Randomized, Phase II, Placebo-Controlled Trial

Michael A. Carducci, Robert J. Padley, Jürgen Breul et al. · Journal of Clinical Oncology · 2003 · 370 citations

Medicine, Oncology, Pharmacology +16