On the Acceptor Substrate of C‐Glycosyltransferase UrdGT2: Three Prejadomycin C‐Glycosides from an Engineered Mutant of <i>Streptomyces globisporus</i> 1912 Δ<i>lndE</i>(<i>urdGT2</i>)

Abstract

The transfer of the gene urdGT2, which encodes a C-glycosyltransferase in the urdamycin pathway, into the lnd-minus mutant of the landomycin (lnd) biosynthetic pathway indicates the difference in the first glycosylation step in the urdamycin and landomycin pathways. It also reveals indirectly the acceptor substrate of UrdGT2 (see scheme) and gives evidence of greatly relaxed substrate specificity of all lnd glycosyltransferases except LndGT2. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z603176_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.