Esomeprazole-Based Helicobacter Pylori Eradication Therapy and The Effect of Antibiotic Resistance: Results of Three Us Multicenter, Double-Blind Trials

Abstract

Ten-day triple therapy with once-daily esomeprazole plus twice-daily amoxicillin and clarithromycin achieves an eradication rate virtually identical to that of the twice-daily proton pump inhibitor-based triple therapies. Baseline clarithromycin resistance, present in 15% of patients, predicts a markedly decreased rate. Use of an amoxicillin-containing regimen may decrease emergence of clarithromycin resistance.